For a long time I have quite angry at ACD/Labs for not providing a good way to get their ChemSketch software for drawing chemical structures to work properly in linux. By default they just deliver a 7 generations older version (version 5.0) of the software for linux. The newest version, 12.0 version, have had a strange bug where it starts and works only at the first start after boot.
When I looked further into the problem, did som google research and such I found a blog called Bridgehead Carbons who discribed a way to solve the problem. But 5 minutes later I resolved an even better way to get the software up and running!
Simple! Instead of using the standard ~/.wine/drive_c/users/[yourusername]/Temp/ACDFREE12/CHEMSK.EXE file to start ChemSketch (the normal an obviously obvious way to start a program) simply double click the shortcut that was made during the install, ~/.wine/drive_c/users/[yourusername]/Temp/ACDLABS 12.0/ChemSketch.lnk. Then your good to do whatever chemistry you like!
There might still be a problem rendering structures in LibreOffice/OpenOffice and such, since there are major problems in the wine shell. But it works!
EDIT 28. august: If your linux shell doesn’t support wine double clicking, you can start ChemSketch from explorer.exe via the same shortcut. Altso, I used wine 1.3, I don’t know if that is relevant.